Influence of biological agents on cardiovascular disease in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Influence of biological agents on cardiovascular disease in rheumatoid arthritis.
A wealth of studies has demonstrated that patients with rheumatoid arthritis (RA) are at increased risk of cardiovascu-lar morbidity and mortality, and that this increase is manifest early in the course of RA. 1 2 Another wealth of studies has shown the increasing effi cacy of recent therapies, or therapeutic strategies, in reducing disease activity in RA. As the infl ammatory burden in RA may ...
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Rheumatoid arthritis (RA) is the commonest inflammatory joint disease with considerable morbidity and mortality. Conventional disease-modifying antirheumatic drugs like methotrexate form the cornerstone of therapy. However, they have several limitations in terms of slow onset of action, adverse effects and modest remission and retention rates. Several cytokines are involved in the pathogenesis ...
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Rheumatoid arthritis (RA) is a multisystem disease with high rates of morbidity and mortality. In recent years, there has been increasing focus on the growing rates of cardiovascular disease (CVD) in RA, over and above expected levels allowing for ‘traditional’ risk factors. In this paper the impact of CVD in RA, the relative contributions of traditional risk factors and novel risk factors (inc...
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Cytokines and Rheumatoid Arthritis The term “cytokine” is coined from the combination of “cyto”, a prefix which means cell, and “kine”, which denotes movement. Cytokines all have the following features: 1. They are low-molecular-weight glycoproteins that are not hormones. 2. They have an effect at very small concentrations. 3. Different cytokines can have the same function (redundancy). For exa...
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Rheumatoid arthritis is characterised by uncontrolled chronic inflammation of the joints, which leads to their destruction and functional disability. It is also associated with increased and early cardiovascular mortality. This is thought to be linked to chronic systemic inflammation, which can lead to accelerated atherosclerosis, and thus earlier and more severe CHD. The beneficial effects of ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2011
ISSN: 0003-4967,1468-2060
DOI: 10.1136/ard.2010.142174